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Mechanism of ATP Synthesis: Model 1 · December 2012

This animation depicts a novel methodology for visualizing the active of ATP synthase during the synthesis of adenosine triphosphate (ATP). This model is based on the x-ray crystallographic structures of three intermediate states in the reaction coordinate of ATP synthesis. The ribbon (in green) represents the backbone structure of the catalytic β subunit. The site is initially bound by adenosine diphosphate (ADP) and inorganic phosphate (Pi), followed by formation of the transition state and later the formation of the product, ATP. This simulation, in comparison to Model 2, illustrates how the absence of Mg2+ in the substrate-bound state disrupts position and orientation of phosphate within the phosphate binding pocket. The methodology and associated research were published in Biochemistry on February 9, 2012 (see abstract).

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